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Instruction of application

Description

White or cream-colored tablets with flat surface.

Composition

One tablet (0.5 g) contains:

Active substance – plant pollen allergic agent from 0.0001 PNU to 1000 PNU

Blister No.1 – 0.0001 PNU, Blister No.2 – 0.001 PNU, Blister No.3 – 0.01 PNU, Blister No.4 – 0.1 PNU, Blister No.5 - 1 PNU, Blister No.6 - 10 PNU, Blister No.7 - 100 PNU, Blister No.8 - 1000 PNU, Blister No.9 - 1000 PNU

Pharmaceutical aids: ascorbic acid, sugar sand, talcum powder.

Pharmacodynamics

Fixed plant-based combination “Antipollin” has double effect:

1) Desensitization of patient to etiologically responsible allergenic agent;

2) Immune stimulation of secondary immunodeficiency.

This helps to increase tolerance to responsible allergenic agent and prevent immune inflammation during sensibilization. Oral administration activates Langerhans cells, which control antigens in submucousal layer before their migration to local lymphatic nodes, where they act as accessory cells. Response of immune system moves from the model Th 2 and Th 1. Patient body decreases synthesis of ig E antibodies and stimulates producing of igG 4.

Indications

“Antipollin” drug is used for specific immune therapy of allergic diseases associated with hypersensitivity to plant pollen, such as seasonal allergic rhinitis, conjunctivitis, urticaria fever, dermatitis, bronchial asthma. Before the therapy patient shall visit allergologist and find the reason that lead to allergy, i.e. responsible  allergic agent (one or several).      

Contradictions

Children up to 5 years and patients over 66 years, patients with severe pollinosis, pregnant and nursing women, patients with serious organic diseases of vital organ, serious chronic infectious diseases (tuberculosis, brucellosis), endocrine organ diseases (diabetes mellitus, goiter), chronic diseases of connective tissue (rheumatism, collagenoses), oncological desiases, AIDS, mental defects.

Drug interactions

It is not recommended to take corticosteroids (hormones), beta-blockers, make prophylactic immunization against infectious diseases.

Special warnings and precautions

It is recommended not to take the drug during flows for women. Do not take tablets with alcoholic drinks.

Adverse events

Adverse events associated with administration of the drug are very rare and usually caused by overdose, presence of specified contradictions and violation of treatment regimen. In the case of itching in mouth, edema on oral mucosa, exacerbation of rhinitis, conjunctivitis, dermatitis and asthma, please, take antihistamine medicine and visit your doctor in order to change treatment regimen.

Dosing and administration

Treatment for all patients shall be assigned by allergologist before initial blossom of responsible plant. Therapy is started from small doses with gradual increase of allergic agent. Tablet shall be put behind the cheek and kept here until complete resorption.

Treatment includes three stages.

Initial therapy

Blister No.1  - one tablet every day

Blister No.2  - one tablet every day

Blister No.3  - one tablet every day

Blister No.4  - one tablet every day

Blister No.5  - one tablet every day

Main therapy

Blister No.6  - one tablet every day

Blister No.7  - one tablet every day

Blister No.8  - one tablet every other day

Final therapy

Blister No.9 – one tablet every one or two days after

If two types of “Antipollin” were assigned, first type shall be taken in the morning and second type shall be taken in the evening.

Drug form and packaging

Tablets.

Every package contains 9 blisters by 6 tablets in each. Kit contains 54 tablets. Every kit is packed into carton box with drug leaflet.

Storage conditions

Drug shall be stored in dry, shadowed place at temperature 10ºС - 25ºС.

Expiry

2 years

Pharmacy purchasing terms

By prescription

Manufacturer

“Burly” Ltd,34 Makatayev street, Almaty, 480019, The Republic of Kazakhstan.

Phone number: 397-75-16, phone/fax; 397-75-17

e-mail: burly@mail.ru

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CONTACT:


18/2 Kunaev Street, Almaty 050002, Kazakhstan

28 Rahimbaev Street, Almaty, 040700, Kazakhstan

E-mail: burlyllp@gmail.com


+7 (727) 389-50-33
+7 (727) 389-51-53
+7 701 577 71 66

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